About Penn State Health Holy Spirit Medical Center

A 306-bed acute care hospital, Penn State Health Holy Spirit Medical Center serves the greater Harrisburg region with outpatient and inpatient diagnostic, medical and surgical services on its East Pennsboro Township, Pa., campus and outpatient locations in Cumberland, Dauphin, Perry and Northern York counties. The four-story Ortenzio Heart Center at Penn State Health Holy Spirit Medical Center is devoted to the care and treatment of patients with heart problems. Its level II trauma center physicians and staff provide around-the-clock complex critical care for those suffering from life-threatening injuries.

Founded in 1963 by the Sisters of Christian Charity, Holy Spirit Medical Center has earned national accreditations for its centers of excellence in the treatment of cardiac care, atrial fibrillation, heart attack (STEMI), heart failure, stroke, diabetes, knee and hip replacement, spine surgery, bariatric surgery and maternity care. Holy Spirit joined Penn State Health in 2020.

Penn State Health Holy Spirit Medical Center is a community Catholic hospital sponsored by the Sisters of Christian Charity to carry out the healing ministry of Jesus Christ to all in need. We provide high-quality, ethically guided and cost-effective health services in a caring, patient-focused environment to develop healthy communities in the greater Harrisburg area and south central Pennsylvania.


Penn State Health Holy Spirit Medical Center will exemplify God’s love through our services and spirit of caring. We will focus on services that provide community value, including:

  • Demonstrated commitment to our healing mission of patient-centered care
  • Innovative, collaborative and relationship-based delivery models
  • Care of the disenfranchised and vulnerable
  • Excellence in clinical quality
  • Outstanding patient and employee satisfaction
  • Sound financial stewardship to ensure our continuing commitment to the community


In our service and our care, we commit ourselves to these values:

  • Dignity - We value the sacredness of life and the dignity of each person.
  • Wholism - We promote the physical, emotional, social and spiritual needs of each person.
  • Service - We meet the needs of others with compassion and competence.
  • Stewardship - We responsibly use the resources entrusted to our care.
  • Quality - We commit ourselves to continuous improvement and to the satisfaction of those we serve.
  • Integrity - We consistently demonstrate high ethical standards and the values of our organization.

Trauma Care

Penn State Health Holy Spirit Medical Center is a Pennsylvania Trauma Systems Foundation accredited Level II Trauma Center. Trauma centers provide around-the-clock complex critical care for patients suffering from life-threatening injuries such as those resulting from motor vehicle accidents, falls and acts of violence. Holy Spirit Medical Center’s trauma team includes a trauma/critical care physician, an emergency medicine physician, neurosurgeons and orthopaedic traumatologists who are supported by surgical and non-surgical specialists and staff from anesthesia, radiology and interventional radiology.

Neonatal Intensive Care Unit (NICU)

If your newborn requires additional medical care, he or she will be cared for in our Neonatal Intensive Care Unit (or NICU) at Holy Spirit Medical Center. Our NICU is staffed 24/7 by neonatologists, neonatal nurse practitioners, neonatal nurses and respiratory therapists — all equipped with special training to provide the care and support your baby needs.  

Located right next to our labor and delivery unit, the Holy Spirit Medical Center NICU cares for premature and term infants requiring specialized care such as continuous cardio-respiratory monitoring, supplemental oxygen, mechanical ventilation and CPAP for respiratory support, IV fluids and IV antibiotics for suspected infections and intensive phototherapy to treat severe jaundice. Should your baby need additional care, transfer to another NICU is available. 

To contact the Holy Spirit Medical Center NICU, call 717-763-2205.

Quality Awards

Over the years, Holy Spirit Medical Center has earned American Heart Association/American Stroke Association Get With The Guidelines (GWTG) honors for our commitment to providing evidence-based heart and stroke care. Holy Spirit Medical Center was the first hospital in Pennsylvania to receive the GWTG Atrial Fibrillation (AFib) Gold award, recognizing us for implementing specific quality improvement measures for the management of patients with atrial fibrillation. We also earned the GWTG Heart Failure Gold Plus award, and the GWTG Stroke Gold Plus award.

We are certified as an Advanced Primary Stroke Center by The Joint Commission, in conjunction with the American Heart Association/American Stroke Association, and we earned Advanced Certification in Inpatient Diabetes Care from The Joint Commission. We are accredited as a Chest Pain Center (primary PCI with resuscitation) by the American College of Cardiology.

Holy Spirit Medical Center earned Highmark Blue Shield Blue Distinction Center designations for cardiac care, spine surgery, and maternity care, as well as Blue Distinction Center+ designations for knee and hip replacement. Blue Distinction Centers are nationally designated healthcare facilities shown to deliver improved patient safety and better health outcomes, based on objective measures that were developed with input from the medical community.

The Holy Spirit Medical Center Breast Care Center earned accreditation from the National Accreditation Program for Breast Centers, a quality program of the American College of Surgeons.

Holy Spirit Medical Center General Surgery’s bariatric program is accredited as a comprehensive center under the Meta­bolic and Bariatric Surgery Accreditation and Quality Improve­ment Program (MBSAQIP®), a joint program of the American College of Surgeons (ACS) and the American Society for Metabolic and Bariatric Surgery (ASMBS).

The Nurses Improving Care for Healthsystem Elders (NICHE) recognizes our commitment to providing positive experiences for the older adults in our care.