Type of cancer that begins in the uterus

Endometrial cancer begins in the lining of the uterus. It is also called uterine cancer. Endometrial cancer is the most common reproductive cancer found in women. The American Cancer Society estimates that more than 61,000 new cases of endometrial cancer are diagnosed each year in the United States

It is more likely to affect post-menopausal women who are over age 60. Endometrial cancer is also slightly more common in white women. Fortunately, when endometrial cancer is found early, it can be more effectively treated.


Gynecologic Oncology at Penn State Cancer Institute provides comprehensive care for women with pelvic malignancies, including endometrial cancer. 

We are also a major site for the National Institutes of Health’s (NIH)-sponsored Gynecologic Oncology Group. This helps us deliver the latest advances in care. 

Our comprehensive services include:

  • Treating cancer, including vaginal, cervical, uterine, fallopian tube and ovarian cancers. Our expertise includes:
    • Chemotherapy
    • Investigational therapies
    • Collaborative treatment plans with local oncologists for chemotherapy, radiation and follow-up treatment
  • Evaluating and treating many gynecological conditions, including:
    • Vulva, vaginal or cervical dysplasia
    • Pelvic masses
    • Abnormal uterine bleeding
    • Endometrial hyperplasia
  • Gynecologic surgery, including medically compromised, or surgically challenging cases
  • Evaluating abnormal or difficult-to-read Pap results
  • Second opinions

Symptoms and Diagnosis

Endometrial cancer begins in the lining of the uterus.


Symptoms of endometrial cancer include:

  • Unusual vaginal bleeding or discharge
  • Pelvic or stomach pain
  • Weight loss

If you have any of these symptoms or any other concerns about your health, then you should schedule an appointment with your provider as soon as possible.


During your appointment, your doctor will do a complete exam, including asking about your personal and family medical history. You will also have a physical and pelvic exam, which will help your doctor identify any unusual symptoms or signs that you may have endometrial cancer.

If your doctor finds anything unusual, you may be referred to a specialist for additional testing, including:

  • An ultrasound to get a clearer picture of your uterus and endometrial lining 
  • A biopsy to check for cancerous cells in endometrial lining

Test results from these exams will help your doctor create a treatment plan that is right for you and your specific cancer. 

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