A trusted leader and global destination for pediatric cancer care
At Penn State Health Children’s Hospital, leading-edge research from Penn State College of Medicine fuels the Pediatric Oncology Division’s commitment to bringing the latest cancer treatments directly from the lab to the bedside. Our expert team combines this innovative science with compassionate, personalized care to treat every type of pediatric cancer. Trusted by families traveling from near and far, we provide advanced therapies and unwavering support throughout their child’s treatment. A key part of their support comes from our partner, Four Diamonds, which ensures eligible families never receive a bill for their child's care.
Welcome. If you’re here, your family may be facing a challenging diagnosis. We want you to know you’re not alone. At every step, we’re here with leading-edge research, breakthrough treatments, access to innovative clinical trials and unwavering support for your entire family. Our Pediatric Hematology and Oncology team is dedicated to providing exceptional care with deep compassion. The children and families we care for are the true heroes who motivate us to work harder and inspire hope.
Giselle Saulnier Sholler, MD
Division Chief, Pediatric Hematology/Oncology/BMT
Why choose us? We won’t stop until every child is cured
At Penn State Health Children’s Hospital, we take pride in providing kids with cancer access to an unmatched level of expertise and comprehensive care that can’t be found anywhere else. Each child has their own unique story and experience, but they all share the same incredible courage and determination. For many, ringing the bell at the end of treatment is a powerful and hopeful moment, but it’s not the end of the journey. Their bravery inspires us every day to keep working toward our goal of finding a cure for every child.
- Recognized by U.S. News & World Report as one of the best children’s hospitals in the nation for pediatric cancer care, the Children’s Hospital has been a source of comprehensive, compassionate cancer care for infants, children and adolescents for more than 25 years.
- We are the lead hospital for the Beat Childhood Cancer Research Consortium, bringing new therapies to children with cancer.
- We are a member of the Children’s Oncology Group, a National Cancer Institute-funded organization dedicated to finding the best new therapies for children with cancer.
- Families from around the world turn to the Children’s Hospital for its unique blend of compassionate, personalized care and the most advanced cancer treatments available. In addition to leading-edge therapies, our expert care teams and top researchers collaborate to offer every child not just treatment, but real hope and the chance to heal.
- Located in Hershey, Pennsylvania, Penn State Health Children’s Hospital provides families with a convenient, accessible place to receive advanced care. We offer:
- Easy access to appointments for patients newly diagnosed with cancer
- Access to health care breakthroughs in clinical trials
- Alternative treatments
- Four Diamonds covers 100 percent of all medical expenses related to cancer care not covered by insurance for eligible Four Diamonds children.
Commitment to childhood cancer research
Located at Penn State Health Milton S. Hershey Medical Center, the only locally based academic medical center in central Pennsylvania, Penn State Health Children’s Hospital is a hub of hope and innovation. Our team of pediatric cancer specialists, in partnership with the researchers at Penn State College of Medicine, is turning groundbreaking discoveries into lifesaving treatments for childhood cancer. We are grateful to Four Diamonds for its generous support in helping to fund this vital research.
Dr. Giselle Saulnier Sholler is an internationally known physician-scientist and founder of the Beat Childhood Cancer Research Consortium based at Penn State College of Medicine and Penn State Health in Hershey. This is an international network of more than 50 children’s hospitals and research institutions dedicated to accelerating precision therapies and clinical trials for pediatric cancers. Sholler, who serves as chief of Penn State Health Children’s Hospital’s Division of Hematology and Oncology, has further elevated our world-class cancer program, making it a destination for pediatric cancer patients from all over the world. Families come, in part, because the U.S. Food and Drug Administration approved eflornithine (DFMO), the first drug to show promising results in reducing the risk of relapses and increasing survival in high-risk pediatric neuroblastoma patients.
Through our membership in the Children’s Oncology Group, the world’s largest organization devoted exclusively to childhood and adolescent cancer research, and our research collaborations with groups like Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC), we are developing safer, more effective treatments. With generous support from Four Diamonds, we make world-class care accessible to families across Pennsylvania, without financial burden.
Clinical trials and research
At any given time, our team will be running studies on pediatric cancer, all in order to advance care at the bedside.
Dedicated oncology specialty teams and programs
Penn State Health Children’s Hospital offers dedicated oncology programs in several specific areas. Our team of specialists will take the time to explain everything you want to know about your child’s diagnosis of cancer. We are here to give you emotional support and explain the treatment options available, including the opportunity for your child to participate in clinical trials.
Brain Tumor Program
Brings together expert neuro-oncologists, neurosurgeons and neuropsychologists to provide comprehensive, personalized care for patients with brain tumors and NF-1.
Integrated Medicine Program
Combines evidence-based complementary therapies with standard cancer care to support the physical, emotional and spiritual well-being of children undergoing treatment. Includes nutrition, acupuncture, massage, Reiki, yoga and art or music therapy that is tailored to reduce symptoms such as pain, anxiety and fatigue.
Leukemia and Lymphoma Program
Provides expert, compassionate care for children and adolescents diagnosed with blood cancers.
Bone Marrow Transplant and Cellular Therapy Program
Offers state-of-the-art treatments for children with high-risk and relapsed cancers, blood disorders and immune deficiencies.
Precision Medicine Program
Is dedicated to delivering individualized cancer care through leading-edge molecular science, including a genetic predisposition clinic.
Survivorship Program
Provides comprehensive, long-term follow-up care for children, adolescents and young adults who have completed cancer treatment. The program focuses on monitoring for late effects of therapy, supporting physical and emotional recovery, and promoting healthy development.
Solid Tumor Program
Offers internationally recognized expertise in the diagnosis and treatment of complex childhood cancers, including neuroblastoma and sarcomas.
Translational Research Program
Offers new, experimental treatments that incorporate leading-edge science to children with all types of cancer, including solid tumors, brain tumors, leukemias and lymphomas.
Unique partnerships critical to care
Four Diamonds
Four Diamonds makes exceptional care and high-risk/high-reward research possible across seven dedicated labs, all focused on finding cures for childhood cancer. Beyond research, it also funds enhanced wrap-around services that care for the whole child, supporting them within their families, schools and communities. Most importantly, Four Diamonds-eligible families never receive a bill for their cancer care, removing the financial burden during an incredibly difficult time.
Watch how Lauryn Six support became personal when she was diagnosed with leukemia
THON
THONTM is a childhood cancer nonprofit organization run by Penn State students. It is dedicated to helping children and families fight the battle by raising funds and awareness, providing comprehensive support and funding innovative research. THON’s sole beneficiary is Four Diamonds.
Penn State College of Medicine
Penn State College of Medicine is at the forefront of leading-edge research and pioneering treatments in the pursuit of curing pediatric cancer. Working closely with Penn State Health clinicians, our experts in the basic sciences turn scientific discoveries into better cancer care. Together, we advance knowledge and medical breakthroughs to improve health outcomes.
Our work is fueled by the hope these medical discoveries bring to our patients and families and by our commitment to improving health worldwide.
Watch how Penn State College of Medicine is Fighting for a Cure
Patient and family support
Penn State Health Children’s Hospital offers comprehensive support services for patients and families to ensure you feel informed, empowered and cared for throughout your child’s health journey.
Adolescent and Young Adult Cancer Program
Meets the unique medical, psychosocial, and developmental needs of patients, ages 15 to 39, navigating cancer diagnosis and treatment. Provides age-appropriate care, fertility preservation counseling, mental health support, peer connections and survivorship planning addressing the challenges of education, career, relationships and independence.
Art Therapy
Provides patients with opportunities for creative self-expression and relaxation.
Bereavement
Offers grief and bereavement support to parents and families in various settings through the Hummingbird Program.
Child Life Program
Provides age-appropriate programming to build coping skills and reduce emotional distress.
Exercise Therapy
Staying active in a safe, guided way during treatment can help preserve your child’s muscle memory and keep them engaged. When balanced with necessary rest, this type of therapy can promote healing, boost mood through the release of endorphins and, in some cases, reduce the need for pain medication.
Facility Dog Program
Uses professionally trained dogs to provide customized patient interventions.
Fertility Preservation
Offers medical procedures that help people protect their ability to have biological children in the future.
Genetic Counseling
Helps diagnose and manage hereditary genetic conditions.
Language Assistance Services
Available for your medical care, free of charge.
Life on Pause Podcast
A podcast for and by young adults living with cancer.
Music Therapy
Uses music and music activities to help children heal and adjust to the hospital.
National and International Patient Support
Provides comprehensive assistance to children and families traveling for cancer care. The program offers help with medical coordination, visa and travel arrangements, language interpretation, and cultural navigation.
Pastoral Services
Provides spiritual and emotional support to patients and families of all faiths.
Patient Education and Resources
Offers treatment for a wide range of mental and behavioral health issues.
Social Work
Supports patients and their families and advocates for their interests.
Our patients are our mission: Hear from other parents
At Penn State Health Children’s Hospital, we take pride in providing kids with cancer access to an unmatched level of expertise and breadth of services that can’t be found anywhere else. Each child has their own unique story and experience, but they all share incredible courage and determination.
This inspires us every day to keep pushing forward in our mission to fight until every child is cured.
Find a Provider
Meet our doctors, view their profiles and select the one that’s right for your child.
Our convenient locations
Penn State Health Children’s Hospital (inpatient/outpatient)
Call: 717-531-6012
Fax referrals and records: 717-531-0332
Pediatric Hematology/Oncology Infusion Clinic
Call: 717-531-6807
FAQs
What is pediatric cancer?
Pediatric cancer refers to cancers that occur in children and adolescents, usually between the ages of 0 and 19. Unlike adult cancers, which are often linked to lifestyle or environmental factors, pediatric cancers are typically caused by genetic mutations early in life. These cancers can affect different parts of the body, such as the blood (leukemia), brain (brain tumors) and organs (neuroblastoma, Wilms tumor, etc.).
What is the most common pediatric cancer?
The most common childhood cancers are leukemia, brain tumors and neuroblastoma. Leukemia, especially acute lymphoblastic leukemia (ALL), affects the blood and bone marrow. Brain tumors, which can occur in various parts of the brain, are the second most common and often require specialized treatment. Neuroblastoma, which mostly affects infants and young children, comes from nerve cells and can spread quickly if not detected early. In addition to these, rare cancers like retinoblastoma (affecting the eyes) and Wilms tumor (a type of kidney cancer) also require fast, effective treatment for the best outcomes.
Can pediatric cancer be cured?
Pediatric cancers tend to be more responsive to treatment, and children often have better survival rates compared to adults diagnosed with cancer. Understanding the symptoms of cancer in children is crucial for early diagnosis and effective treatment.
What pediatric cancer conditions do we treat?
We treat all pediatric blood disorders and cancers, including the following.
Leukemias
- Acute lymphoblastic leukemia (ALL)
- Acute myelocytic leukemia (AML)
- Chronic myelocytic leukemia (CML)
- Juvenile chronic myelogenous leukemia (JCML)
- Juvenile myelomonocytic leukemia (JMML)
Brain and central nervous system (CNS) tumors
- Medulloblastoma
- Primitive neuroectodermal tumor (PNET)
- Ependymoma
- Astrocytoma (high grade, cerebellar, low grade)
- Glioblastoma
- Brainstem gliomas
- Central nervous system (CNS) germ cell tumors
Solid tumors
- Non-Hodgkin’s lymphoma
- Hodgkin’s lymphoma
- Neuroblastoma
- Wilms’ tumor
- Rhabdomyosarcoma
- Bone tumors
- Ewing’s sarcoma
- Osteosarcoma
- Hepatoblastoma
- Germ cell tumors
Lymphomas
- Retinoblastoma
- Non-Hodgkin’s lymphoma
Blood Disorders
- Hemophilia
- Sickle cell anemia
- Thrombotic disorders
Other Conditions
- Neurofibromatosis Type 1
What treatment options are available?
- Chemotherapy and novel targeted therapies: Medicines that kill cancer cells or block specific changes in cancer cells to stop them from growing.
- Immunotherapy: Boosts your body’s natural defenses to fight cancer using treatments like special antibodies, cancer vaccines or CAR T-cell therapy.
- Radiation therapy: Uses powerful energy (like X-rays) to destroy cancer cells.
- Surgery/neurosurgery: Expert surgeons remove tumors, even in complex or delicate areas.
- Interventional radiology: Minimally invasive procedures guided by imaging (like MRI or CT scans) to treat tumors, including advanced options like Gamma Knife, ablation or blocking blood flow to tumors.
- Clinical trials: Research on targeted therapies gives our patients access to the latest cancer treatments.
