Rivaroxaban Assay

Test Name

Rivaroxaban Assay

Alternate Description

Xarelto Level

LIS Code

RIVL

Lab Section

Special Hematology

Fluid Type

Whole Blood (citrated plasma)

Summary Test Name

Rivaroxaban Assay

Specimen Stability

28 days frozen

Minimum Volume

1 full sodium citrate light blue top tube

Specimen Preparation In House

Spin at 2500g for 20 min.  Remove plasma and freeze. 

Stat Availability

Not available

Test Turnaround Time Routines And Stats

7 working days

Reference Value

Recommended therapeutic range based on published data(1) :

Dosage    Peak (ng/ml) (2)    Trough (ng/ml) (3)
20 mg OD  182-408 3-153
15 mg OD 180-408  2-161
10 mg OD 127-235 5-22

(1) 20mg and 15 mg = European Medicines Agency Assessment Report, 2012 10mg = Clinical Pharmacokinetics and Pharmacodynamic Profile of Rivaroxaban, 53(1):1-16 (2014)

(2) Peak = 2 - 4 hours post dose

(3) Trough = 20-26 hours 

Additional Test Information

1) Methodology - Rivaroxaban is a direct anti-Xa anticoagulant molecule whose activity can be determined with a chromogenic anti-Xa assay and calibrators specific to rivaroxaban. 

2) Known interferences are UFH, LMWH, fondaparinux, apixaban, and any substance known to be a Xa inhibitor. 

3) The coefficient of variation for this assay is 3.6%. 

4) The lower limit of detection for this method is 30ng/ml.